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It is possible that we only detected cytoplasmic GPX4 because of its abundant endogenous distribution compared with that of mitochondrial or nucleolus GPX4

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FIGURE 7 4 Discussion Inflammatory lung injury is a hallmark pathological feature of pneumonia caused by diverse infectious and non-infectious stimuli, including bacterial endotoxins, allergens, and environmental irritants (Zhang et al., 2024

however, it is also expressed in reactive astrocytes, endothelial cells, and vascular smooth muscle cells in AD brains (Gui et al., 2020)